Guojun Bu Selected Research

Tauopathies

1/2023	Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology.
10/2018	APOE ε2 is associated with increased tau pathology in primary tauopathy.
1/2018	Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Guojun Bu Research Topics

Disease

132	Alzheimer Disease (Alzheimer's Disease) 04/2024 - 01/2004
17	Dementia (Dementias) 10/2023 - 01/2014
15	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2023 - 02/2011
13	Amyloid Plaque 02/2024 - 07/2005
13	Neuroinflammatory Diseases 10/2023 - 12/2010
12	Cognitive Dysfunction 04/2024 - 01/2013
12	Neoplasms (Cancer) 01/2017 - 12/2004
8	Gliosis 01/2023 - 05/2015
7	Lewy Body Disease (Lewy Body Dementia) 10/2023 - 01/2020
6	Parkinson Disease (Parkinson's Disease) 01/2023 - 11/2011
5	Inflammation (Inflammations) 01/2023 - 11/2005
5	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 10/2020 - 12/2007
4	Carcinogenesis 02/2024 - 12/2004
4	Amyloidosis 01/2022 - 01/2017
4	Frontotemporal Dementia (Semantic Dementia) 01/2020 - 09/2015
3	Stomach Neoplasms (Stomach Cancer) 02/2024 - 03/2015
3	Tauopathies 01/2023 - 01/2018
3	Synucleinopathies 01/2023 - 01/2020
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2023 - 10/2020
2	Multiple System Atrophy 01/2023 - 01/2018
2	Obesity 01/2023 - 01/2011
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2023 - 01/2016
2	Demyelinating Diseases (Demyelinating Disease) 11/2022 - 01/2020
2	COVID-19 01/2022 - 01/2020
2	Chronic Renal Insufficiency 01/2022 - 01/2022
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022 - 01/2020
2	Cerebrovascular Disorders (Cerebrovascular Occlusion) 11/2020 - 01/2020
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 10/2018 - 09/2015
2	Epilepsy (Aura) 01/2018 - 01/2016
2	Prostatic Neoplasms (Prostate Cancer) 01/2013 - 06/2010
2	Memory Disorders (Memory Loss) 12/2010 - 01/2004
2	Breast Neoplasms (Breast Cancer) 03/2010 - 09/2008
2	Neoplasm Metastasis (Metastasis) 10/2009 - 09/2008
2	Glioma (Gliomas) 03/2009 - 08/2004
2	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 06/2004 - 04/2002
1	TDP-43 Proteinopathies 01/2023
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2023
1	Disease Progression 12/2021
1	Atherosclerosis 01/2021
1	Hypercholesterolemia 01/2021
1	Nervous System Diseases (Neurological Disorders) 11/2020
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 10/2020
1	Ataxia (Dyssynergia) 10/2020

Drug/Important Bio-Agent (IBA)

69	Amyloid (Amyloid Fibrils)IBA 02/2024 - 01/2004
57	Apolipoproteins E (ApoE)IBA 02/2024 - 01/2005
45	ApolipoproteinsIBA 06/2023 - 04/2005
33	Proteins (Proteins, Gene)FDA Link 10/2023 - 01/2004
32	Apolipoprotein E4IBA 11/2023 - 10/2006
29	Peptides (Polypeptides)IBA 11/2020 - 07/2005
16	Amyloid beta-PeptidesIBA 01/2023 - 01/2004
14	Protein Isoforms (Isoforms)IBA 06/2023 - 12/2012
12	Apolipoprotein E3IBA 11/2023 - 01/2014
12	Apolipoprotein E2IBA 01/2023 - 01/2014
8	Biomarkers (Surrogate Marker)IBA 04/2024 - 01/2017
8	LDL Receptors (LDL Receptor)IBA 01/2017 - 04/2002
7	LipidsIBA 11/2022 - 12/2010
7	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2014 - 09/2007
6	CholesterolIBA 01/2023 - 01/2005
5	SynucleinsIBA 01/2022 - 11/2011
4	ProgranulinsIBA 10/2020 - 01/2016
4	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 01/2013
4	EnzymesIBA 12/2017 - 08/2004
4	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 12/2016 - 04/2008
3	CateninsIBA 01/2023 - 01/2013
3	beta CateninIBA 06/2010 - 12/2004
3	LigandsIBA 02/2009 - 04/2005
2	Cyclin-Dependent Kinase 5IBA 02/2024 - 03/2015
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2023 - 07/2013
2	CuprizoneIBA 11/2022 - 01/2020
2	Insulin (Novolin)FDA Link 01/2022 - 09/2017
2	Adenosine Triphosphate (ATP)IBA 01/2021 - 04/2015
2	UbiquitinIBA 01/2021 - 10/2020
2	LipopolysaccharidesIBA 11/2019 - 11/2018
2	Kainic Acid (Kainate)IBA 01/2018 - 01/2016
2	Presenilin-1IBA 01/2017 - 05/2014
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2016 - 11/2005
2	MicroRNAs (MicroRNA)IBA 04/2013 - 10/2009
2	MidkineIBA 03/2011 - 11/2007
2	Lipoprotein Receptors (Lipoprotein Receptor)IBA 01/2011 - 04/2009
2	Pregnancy-Associated alpha 2-Macroglobulins (alpha 2 Macroglobulin)IBA 03/2009 - 04/2005
1	ChitinasesIBA 10/2023
1	NeurocalcinIBA 10/2023
1	NeurograninIBA 10/2023
1	Glial Fibrillary Acidic ProteinIBA 10/2023
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 10/2023
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 10/2023
1	alpha-SynucleinIBA 01/2023
1	RNA (Ribonucleic Acid)IBA 11/2022
1	ElementsIBA 11/2022
1	Lipoproteins (Lipoprotein)IBA 01/2022
1	PrionsIBA 01/2022
1	Serine (L-Serine)FDA Link 01/2021
1	Alkaline PhosphataseIBA 01/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2021
1	Ataxin-3IBA 10/2020
1	polyglutamineIBA 10/2020
1	lysosomal proteinsIBA 10/2020

Therapy/Procedure

12	Therapeutics 12/2022 - 06/2005
2	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2022 - 01/2020
1	Investigational Therapies (Experimental Therapy) 12/2019